| |
Currently there are two active research projects in the Department. One is strategic funded research project titled Family and Genetic Understanding of Autosomal Recessive Disorders: A Clinical Genetic, Cytogenetic, Molecular and Linkage Study in Oman. This project investigates a variety of autosomal recessive inherited disorders with the aim of identifying chromosomal loci. The second project is titled cytogenetics and moelcular characterization of chronic myeloid leukaemia, which examines the chromosomal structural aberrations as well as the DNA alterations in order to categorize and determine the chromosomal abnormalities and fusion transcripts within the Omani population.
The department has been participating and leading several other research projects over the last 8 years and the following are the supporting publications from the investigations:
1. Al-Moundhri MS, Alkindy M, Al-Nabhani M, Al-Bahrani B, Burney IA, Al-Habsi H, Ganguly SS, Tanira M. Combined polymorphism analysis of glutathione S-transferase M1/G1 and interleukin-1B (IL-1B)/interleukin 1-receptor antagonist (IL-1RN) and gastric cancer risk in an Omani Arab Population. J Clin Gastroenterol. 2009 Feb;43(2):152-6.
2. Alansari AS, Al-Moundhri M, Al-Nabhani MM, Al-Zidjali SA. BRCA1 2080insA mutation in familial breast cancer. Breast Cancer Res Treat. 2009 Feb;113(3):605-6.
3. Udayakumar AM, Pathare AV, Dennison D, Raeburn JA. Acquired Pericentric Inversion of Chromosome 9 in Acute Myeloid Leukemia. Journal of Applied Genetics 2009, 50(1)73-76.
4. Al-Moundhri MS, Al-Shukaili A, Al-Nabhani M, Al-Bahrani B, Burney IA, Rizivi A, Ganguly SS. Measurement of circulating levels of VEGF-A, -C, and -D and their receptors, VEGFR-1 and -2 in gastric adenocarcinoma. World J Gastroenterol. 2008 Jun 28;14(24):3879-83.
5. Dick KJ, Al-Mjeni R, Baskir W, Koul R, Simpson MA, Patton MA, Raeburn S, Crosby AH. A novel locus for an autosomal recessive hereditary spastic paraplegia (SPG35) maps to 16q21-q23. Neurology. 2008 Jul 22; 71(4):248-52.
6. Brim H, Mokarram P, Naghibalhossaini F, Saberi-Firoozi M, Al-Mandhari M, Al-Mawaly K, Al-Mjeni R, Al-Sayegh A, Raeburn S, Lee E, Giardiello F, Smoot DT, Vilkin A, Boland CR, Goel A, Hafezi M, Nouraie M, Ashktorab H. Impact of BRAF, MLH1 on the incidence of microsatellite instability high colorectal cancer in populations based study. Mol Cancer. 2008 Aug 21; 7:68.
7. Ashktorab H, Brim H, Al-Riyami M, Date A, Al-Mawaly K, Kashoub M, Al-Mjeni R, Smoot DT, Al-Moundhri M, Al-Hashemi S, Ganguly SS, Raeburn S. Sporadic colon cancer: mismatch repair immunohistochemistry and microsatellite instability in Omani subjects. Dig Dis Sci. 2008 Oct; 53(10):2723-31.
8. Udayakumar AM , Alkindi S , Pathare AV , Raeburn JA. Complex t(8;13;21)(q22;q14;q22) – a novel variant of t(8;21) in a Patient with Acute Myeloid Leukemia (AML – M2) Arch Med Res ( USA) (2008) 39 : 252-256
9. Udayakumar AM, Pathare AV, Al Kindi S, Khan H, Rahman J, Fehmida Z, Al Ghazaly, Nusrut N, Khan I, Wali Y, Al Lamki Z, Dennison D, Raeburn JA. Cytogenetic, morphological and immunophenotypic pattern in Omani patients with de novo acute myeloid leukemia. Cancer Genet Cytogenet 2007; 177:89-94.
10. Udayakumar AM, Pathare AV, Muralitharan S, Al Ghazaly AA, Al Kindi S, Raeburn J. Trisomy 21 as a sole acquired abnormality in an adult omani patient with CD 7 and CD 9 positive acute myeloid leukaemia, Arch Med Res 2007; 38: 797-802.
11. Udayakumar AM, Pathare AV, Al Kindi S, Raeburn J. Biphenotypic leukemia with interstitial del (9) (q22q32) as a sole abnormality. Cancer Genet Cytogenet 2007; 178:170-172.
12. Udayakumar AM, Bashir WA, Pathare AV, Wali YA, Zacharia M, Khan A, Soliman H, Al Lamki Z, Raeburn J. Cytogenetic profile of childhood acute lymphoblastic leukemia in Oman, Arch Med Res 2007; 38:305-312.
13. Hassan Ashktorab, Hassan Brim, Marwa Al-Riyami, Anand Date, Kamla Al-Mawaly, Masoud Kashoub, Rayhaneh Al-Mjeni, Duane T. Smoot, Mansour Al-Mandhari , Suleiman Al-Hashemi, Shyam S. Ganguly, and Sandy Raeburn. Sporadic colon cancer: Mismatch repair and microsatellite instability genes in Omani subjects. Digestive Disease Science. Digestive Diseases and Sciences. December 2007;53;(10) 0163-2116.
14. Al-Moundhri MS, Al-Kindi M, Al-Nabhani M, Al-Bahrani B, Burney IA, Al-Madhani A, Ganguly SS, Tanira M. NAT2 polymorphism in Omani gastric cancer patients-risk predisposition and clinicopathological associations. World J Gastroenterol. 2007 May 21;13(19):2697-702.
15. Al-Moundhri MS, Al-Bahrani B, Burney IA, Nirmala V, Al-Madhani A, Al-Mawaly K, Al-Nabhani M, Thomas V, Ganguly SS, Grant CS. The prognostic determinants of gastric cancer treatment outcome in Omani Arab patients. Oncology. 2006;70(2):90-6.
16. Ganesh A, Nishimura D, Rattenberry E, Ahmed S, Smith UM, Pasha S, Raeburn J, Trembath RC, Rajab A, Macdonald F, Banin E, Stone EM, Johnson CA, Sheffield VC, MaherER. Autozygosity mapping of Bardet–Biedl syndrome to 12q21.2 and confirmation of FLJ23560 as BBS10 White DRA. Eur J Hum Genet 2006; 15:173-178.
17. Mansour S. Al-Moundhri1, Mariam Al-Nabhani, Bassim Al-Bahrani, Ikram A. Burney1, Ali Al-Madhani, Shym S. Ganguly, Said A. Al-Yahyaee, and Christopher S. Grant. Interleukin-1b gene (IL-1B) and interleukin 1 receptor antagonist gene (IL-1RN) polymorphisms and gastric cancer risk in an Omani Arab population. Gastric Cancer 2006;9(4):284-90
18. Al-Moundhri MS, Nirmala V, Al-Hadabi I, Al-Mawaly K, Burney I, Al-Nabhani M, Thomas V, Ganguly SS, Grant C. The prognostic significance of p53, p27 kip1, p21 waf1, HER-2/neu, and Ki67 proteins expression in gastric cancer: a clinicopathological and immunohistochemical study of 121 Arab patients. J Surg Oncol. 2005 Sep 15;91(4):243-52.
19. Zakia Al-Lamki, Yasser A. Wali, Shah M. Wasifuddin, Mathew Zachariah, Rayhanah Al-Mjeni, Changping Li, Shanmugakonar Muralitharan, Khalsa Al-Kharusi, Preethi Gunaratne, Leif Peterson, Richard Gibbs, Marie-Claude Gingras, Judith F. Margolin. Identification of prognosis markers in pediatrics High-Risk Acte Lymphoblastic Leukemia. Pediatric Hematology and Oncology, 2005 Oct-Nov: 22: 7: 629 – 643
20. Simsek M, Al-Ghazali L, Al-Mjeni R, Bayoumi R. Improved Diagnosis of A Common Mutation (R248C) In The Human Growth Factor Receptor 3 (FGFR3) gene that causes type I Thanatophoric Dysplasia. Clinical Biochemistry, 2003 Mar: 36: 2: 151-153.
|
|