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Research
   2009 - 2010
 RESEARCH PROJECTS
  • From Gene Expression Analysis of Omani Breast Tumours to Biomarkers/Candidate Gene Discovery
Project Code: SR/MED/GENT/10/01; Dates: 2010–2011
Value: OR 207,850; Project Funder: His Majesty’s Strategic Research Fund, Oman
Investigators: Dr. Allal Ouhtit, Dept. Genetics, SQU; Dr. Yahya Al-Tamimi, Dept. Biochemistry, SQU; Dr. Mansour Al-Moundhri, Dept. Medicine, SQU; Dr. Said Al-Yahyaee, Dept. Genetics, SQU; Prof. Madhwa HG Raj, LSU Health Sciences Center, 
New Orleans, USA; Prof. Herlyn Meenhard, Dept. Dermatology, Wistar Institute, Pennsylvania, USA. 
Molecular Epidemiology and Diagnosis Study of Common Inborn Errors of Metabolism Disorders in 
Oman and UAE
Project Code: CL-SQU/UAE/10/01; Dates: 2010–2011
Value: OR 20,000; Project Funder: Sultan Qaboos University and UAE University 
Investigators: Dr Said Al-Yahyaee, Dept. Genetics SQU; Dr. Bassam R.Ali, Dept. Pathology, UAE University; Dr. Allal Ouhtit, Dept. Genetics, SQU; Prof. Yousef Abdulrazzaq, Dept. Paediatrics, UAE University; Dr. Jozef Hertecant, Dept. Paediatrics, Tawam Hospital, UAE; Dr Mahera Abdulrahman, Dubai Genetics Center, UAE; Dr. Hussein Al-Kindi, Dept. Child Health, SQU; Dr. SN Joshi, Dept. Child Health, SQU.

  • Family and Genetic Understanding of Autosomal Recessive Disorders: A Clinical Genetic, Cytogenetic, Molecular and Linkage Study in Oman.
Project Code: SR/MED/GENT /06 /01; Dates: 2006–2011
Value: OR 168,850; Project Funder: His Majesty’s Strategic Research Fund, Oman
Investigators: Prof. John Raeburn, Dept. Genetics, SQU; Dr. Aisha Al-Khayat, Dept. Biology, SQU; Dr. Ahmed Al-Mandhari, Dept. Family Medicine & Public Health, 
SQUH; Dr. A.M Udayakumar, Dept. Genetics, SQU; Ms. Rayhana Al-Mjeni,
Dept. Genetics, SQU; Dr. Shyam Gangly, Dept. Epidemiology & Statistics, 
SQU; Dr. Mohamed Al-Shafaee, Dept. Family Medicine & Public Health, SQU; 
Dr. Anuradha Ganesh, Dept. Ophthalmology, SQUH; Prof. Riad Bayoumi, 
Dept. Biochemistry, SQU; Dr. Yasser Wali, Dept. Child Health, SQU; Dr. David 
Dennison, Dept. Haematology, SQU.
Cytogenetics and Molecular Characterization of Chronic Myeloid Leukaemia 
Project Code: IG/MED/GENE /08/01; Dates: 2008–2010
Value: OR 5,500; Project Funder: Sultan Qaboos University
Investigators: Dr. A.M. Udayakumar, Dept. Genetics, SQU; Dr. Salam Al-Kindi, Dept. Haematology, SQU.
Assessment of the Role of Consanguinity & Cytogenetic Abnormalities in Individuals with Recurrent 
Miscarriage among Omani population
Project Code: MREC# 345; Dates: 2010
Value: Unfunded; Project Approval: Sultan Qaboos University
Investigator: Dr. A.M. Udayakumar, Dept. Genetics, SQU; 6th & 7th year students of Genetics Dept., SQU.
  • Molecular Epidemiology and Diagnosis of Common Inborn Errors of Metabolism Disorders in Oman and UAE
Project Code: MREC# 354; Dates: 2010
Value: Unfunded; Project Approval: Sultan Qaboos University
Investigators: Dr. Said Al-Yahyaee, Dept. Genetics, SQU
Establishment of Molecular Genetics Diagnostics
Project Code: MREC# 356; Dates: 2010
Value: Unfunded; Project Approval: Sultan Qaboos University
Investigators: Dr. Allal Ouhtit, Dept. Genetics, SQU
Signal transduction mechanisms of CD146 cell adhesion receptor in Breast Cancer in Oman
Project Code: MREC# 334; Dates: 2010
Value: Unfunded; Project Approval: Sultan Qaboos University
Investigator: Dr. Allal Ouhtit, Dept. Genetics, SQU.
RESEARCH PUBLICATIONS & BOOKS
Journal Publications 
1. Ouhtit A, Trappy A, Fernando A, Gaur R, Raj M. The shady side of sunlight: Current understanding of the mechanism 
underlying UV-induction of skin cancers. Front Biosci (Schol Ed). 2010; 2:11−7

   2007 - 2009
RESEARCH PROjECTS
  • Family and Genetic Understanding of Autosomal Recessive Disorders: A Clinical Genetic, Cytogenetic, Molecular and Linkage Study in Oman
Project Code: SR/MED/GENT/06/01
Dates: 2006-2009
Value: OR 168,850
Project Funder: His Majesty’s Strategic Research Fund
Investigators: Prof. John Raeburn, Department of Genetics, SQU; Dr. Aisha AlKhayat, Department of Biology, SQU; Dr. Ahmed Al-Mandhari, Department of Family Medicine & Public Health, SQUH; Ms. Rayhana 
Al-Mjeni,Department of Genetics, SQU; Dr. Shyam Ganguly, Department of Epidemiology & Statistics, SQU; Dr. Mohamed Al-Shafaee,
Department of Family Medicine & Public Health, SQU; Dr. Anuradha 
Ganesh, Department of Ophthalmology, SQUH; Prof. Riad Bayoumi,
Department of Biochemistry, SQU; Dr. Yasser Wali, HOD, Department 
of Child Health, SQU; Dr. AM Udayakumar, Department of Genetics, SQU; Dr. David Dennison, Department of Haematology, SQU
Cytogenetics and Moelcular Characterization of Chronic Myeloid Leukemia
Project Code: IG/MED/GENE /08/01
Dates: 2008-2010
Value: OR 5,500
Investigators: Dr. AM Udayakumar, Department of Genetics, SQU; Dr. Salam AlKindi, Department of Haematology, SQU 


RESEARCH PUBLICATIONS AND BOOkS
  • Journal Publications
1. Udayakumar AM, Alkindi S , Pathare AV , Raeburn JA. Complex t(8;13;21)(q22;q14;q22) - a novel 
variant of t(8;21) in a Patient with Acute Myeloid Leukemia (AML - M2). Arch Med Res ( USA) 2008; 
39:252-6.
2. Udayakumar AM, Bashir WA, Pathare AV, Wali YA, Zacharia M, Khan A, Soliman H, Al-Lamki Z, Raeburn 
J. Cytogenetic profile of childhood acute lymphoblastic leukemia in Oman. Arch Med Res 2007; 38:305-12.
3. Udayakumar AM, Pathare AV, Al-Kindi S, Khan H, Rahman J, Fehmida Z, Al-Ghazaly, Nusrut N, Khan I, 
Wali Y, Al-Lamki Z, Dennison D, Raeburn JA. Cytogenetic, morphological and immunophenotypic pattern in 
Omani patients with de novo acute myeloid leukemia. Cancer Genet Cytogenet 2007; 177:89-94. 
4. Udayakumar AM, Pathare AV, Muralitharan S, Al-Ghazaly AA, Al-Kindi S, Raeburn J. Trisomy 21 as a sole 
acquired abnormality in an adult omani patient with CD 7 and CD 9 positive acute myeloid leukaemia, Arch 
Med Res 2007; 38:797-802. 
6. Udayakumar AM, Pathare AV, Al-Kindi S, Raeburn J. Biphenotypic leukemia with interstitial del (9) (q22q32) 
as a sole abnormality. Cancer Genet Cytogenet 2007; 178:170-2. 
7. Al-Moundhri MS, Al-Shukaili A, Al-Nabhani M, Al-Bahrani B, Burney IA, Rizivi A, Ganguly SS. Measurement of circulating levels of VEGF-A, -C, and -D and their receptors, VEGFR-1 and -2 in gastric adenocarcinoma. World J Gastroenterol. 2008; 14:3879-83. 
8. Dick KJ, Al-Mjeni R, Baskir W, Koul R, Simpson MA, Patton MA, Raeburn S, Crosby AH. A novel locus for 
an autosomal recessive hereditary spastic paraplegia (SPG35) maps to 16q21-q23. Neurology 2008; 71:248-52. 
9. Brim H, Mokarram P, Naghibalhossaini F, Saberi-Firoozi M, Al-Mandhari M, Al-Mawaly K, Al-Mjeni R, AlSayegh A, Raeburn S, Lee E, Giardiello F, Smoot DT, Vilkin A, Boland CR, Goel A, Hafezi M, Nouraie M, 
Ashktorab H. Impact of BRAF, MLH1 on the incidence of microsatellite instability high colorectal cancer in 
populations based study. Mol Cancer 2008; 7:68. 
10. Ashktorab H, Brim H, Al-Riyami M, Date A, Al-Mawaly K, Kashoub M, Al-Mjeni R, Smoot DT, Al-Moundhri 
M, Al-Hashemi S, Ganguly SS, Raeburn S. Sporadic colon cancer: mismatch repair immunohistochemistry and 
microsatellite instability in Omani subjects. Dig Dis Sci 2008; 53:2723-31. 
11. Udayakumar AM, Pathare AV, Al-Kindi S, Khan H, Rahman J, Fehmida Z, Al-Ghazaly, Nusrut N, Khan I, 
Wali Y, Al-Lamki Z, Dennison D, Raeburn JA. Cytogenetic, morphological and immunophenotypic pattern in 
Omani patients with de novo acute myeloid leukemia. Cancer Genet Cytogenet 2007; 177:89-94. 
12. Ashktorab H, Brim H, Al-Riyami M, Date A, Al-Mawaly K, Kashoub M, Al-Mjeni R, Smoot DT, Al-Mandhari M, Al-Hashemi S, Ganguly SS, Raeburn S. Sporadic colon cancer: Mismatch repair and microsatellite 
instabilitygenes in Omani subjects. DigestDisease Sci 2007; 53; 0163-2116. 
13. Al-Moundhri MS, Al-Kindi M, Al-Nabhani M, Al-Bahrani B, Burney IA, Al-Madhani A, Ganguly SS, 
Tanira M. NAT2 polymorphism in Omani gastric cancer patients-risk predisposition and clinicopathological 
associations. World J Gastroenterol 2007; 13:2697-702.


   2005 - 2007
Research Projects
Strategic funded researcH Project 
  • Family and Genetic Understanding of Autosomal Recessive Disorders: A Clinical Genetic, Cytogenetic, Molecular and Linkage Study in Oman
Project Code: SR/MED/GENT /06 /01
Dates: 2006
Value: OR 168,850
Investigators: Prof. John Raeburn, Department of Genetics, SQU; Dr. Aisha Al-Khayat, Department 
of Biology, SQU; Dr. Ahmed Al-Mandhari, Department of Family Medicine & Public Health, SQUH; Ms. Rayhana Al-Mjeni, Department of Genetics, SQU; Dr. Shyam 
Ganguly, Department of Epidemiology & Statistics, SQU; Dr. Mohamed Al-Shafaee,
Department of Family Medicine & Public Health, SQU; Dr. Anuradha Ganesh, Department of Ophthalmology, SQUH; Prof. Riad Bayoumi, Department of Biochemistry, SQU; Dr. Yasser Wali, HOD, Department of Child Health, SQU;Dr. AM Udayakumar, Department of Genetics, SQU; Dr. David Dennison, Department of Haematology, SQU
internAlly funDeD reseArCH ProjeCts 
A study of the SMN1 exon 7 deletion frequency in populations from 2 regions of Oman
Project Code: IG/MED/GENE /06/01
Dates: 2006-2008
Value: OR 14,930
Investigators: Prof. John Raeburn, Department of Genetics, SQU; Dr. Shyam Ganguli, Department of Family Medicine & Public Health, SQU; Dr. Mehmet Simsek, Department of Biochemistry, SQU; Dr. Abeer Al-Sayegh, Department of Genetics, SQU; Ms. Rayhana 
Al-Mjeni, Department of Genetics, SQU

  • Projects led by otHer Departments with Co-investigators in this Department

Clinical Profile and Molecular Basis of Severe Combined Immunodeficiency Syndromes in Oman (Child 
Health)
Co-investigator: Prof. Sandy Raeburn 
Delaying the Onset of Type 2 Diabetes mellitus in Oman – The AMAL study (Family Medicine & Public 
Health)
Co-investigator: Prof. Sandy Raeburn
Towards A Balanced Assessment of Consanguineous Marriage in Oman (Family Medicine & Public 
Health)
Co-investigator: Dr. Alan Bittles
Epigenetics of Gastric Cancer in Oman and Helicobacter Pylori genotyping (Medicine)
Co-investigators: Ms. Maryam Al-Nabhani
Monogenic Diabetes Mellitus in Oman. A search for established and novel gene mutations (Medicine)
Co-investigators: Prof. Sandy Raeburn
Pseudoexfoliation (PEX) Glaucoma Blindness in Oman (Ophthalmology)
Co-investigator: Prof. John Raeburn 
Hypertension and the Metabolic Syndrome in Oman Intervention Clinical Trial and Mapping of Genes 
(Physiology)
Co-investigators: Dr. Said Al-Yahyaee

Research Publications and Books
journal publication
1. Udayakumar AM,Bashir WA, Pathare AV, Wali YA,Zacharia M, Khan A, Soliman H, Al-Lamki Z, Raeburn J.
Cytogenetic profile of childhood acute lymphoblastic leukemia in Oman, Arch Med Res 2007; 38:305-312.
2. Ganesh A, Nishimura D, Rattenberry E, Ahmed S, Smith UM, Pasha S, Raeburn J, Trembath RC, Rajab A, Macdonald F, Banin E, Stone EM, Johnson CA, Sheffield VC, MaherER. Autozygosity mapping of Bardet–Biedl syndrome to 12q21.2 and confirmation of FLJ23560 as BBS10 White DRA. Eur J Hum Genet 2006; 15:173-178.
3. Udayakumar AM, Pathare AV, Al-Kindi S, Khan H, Rahman J, Fehmida Z, Al-Ghazaly, Nusrut N, Khan I, Wali Y, Al-Lamki Z, Dennison D, Raeburn JA. Cytogenetic, morphological and immunophenotypic pattern in Omani patients with de novo acute myeloid leukemia. Cancer Genet Cytogenet 2007; 177:89-94. 
4. Udayakumar AM, Pathare AV, Muralitharan S, Al-Ghazaly AA, Al-Kindi S, Raeburn J. Trisomy 21 as a sole acquired abnormality in an adult omani patient with CD 7 and CD 9 positive acute myeloid leukaemia, Arch Med Res 2007; 38: 797-802.
5. Udayakumar AM, Pathare AV, Al-Kindi S, Raeburn J. Biphenotypic leukemia with interstitial del (9) (q22q32) as a sole abnormality. Cancer Genet Cytogenet 2007; 178:170-172.


 
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